Edematogenic responses induced by Bothrops jararaca venom in rats: role of lymphocytes
Identifieur interne : 00C930 ( Main/Exploration ); précédent : 00C929; suivant : 00C931Edematogenic responses induced by Bothrops jararaca venom in rats: role of lymphocytes
Auteurs : Y. Cury [Brésil] ; C. F. P. Teixeira [Brésil] ; L. S. Sudo [Brésil]Source :
- Toxicon [ 0041-0101 ] ; 1994.
Abstract
Y. Cury, C. F. P. Teixeira and L. S. Sudo. Edematogenic responses induced by Bothrops jararaca venom in rats: role of lymphocytes. Toxicon32, 1425–1431, 1994.—The intraplantar injection of Bothrops jararaca venom (Bjv) caused an edematogenic response in the rat which was of rapid onset, and reached a peak in about 60 min. The response was markedly attenuated in animals rendered leucopenic by the administration of amethopterin. This inhibition was partially reverted when leucopenic rats were given i.v. suspensions of lymphocytes. Suspensions of neutrophils were ineffective. If the animals were submitted to an experimental obstruction of the thoracic duct, which leads to specific lymphocytopenia, similar inhibition of the edematogenic response was observed. These results suggest that lymphocytes can directly influence the development of the edema induced by Bothrops jararaca venom.
Url:
DOI: 10.1016/0041-0101(94)90414-6
Affiliations:
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Cury</name><affiliation wicri:level="2"><country xml:lang="fr">Brésil</country><wicri:regionArea>Laboratory of Pathophysiology, Butantan Institute, Av. Vital Brazil, 1500, 05503-900, São Paulo, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Teixeira, C F P" sort="Teixeira, C F P" uniqKey="Teixeira C" first="C. F. P." last="Teixeira">C. F. P. Teixeira</name><affiliation wicri:level="2"><country xml:lang="fr">Brésil</country><wicri:regionArea>Laboratory of Pharmacology, Butantan Institute, Av. Vital Brazil, 1500, 05503-900, São Paulo, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Sudo, L S" sort="Sudo, L S" uniqKey="Sudo L" first="L. S." last="Sudo">L. S. Sudo</name><affiliation wicri:level="4"><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 1524, 05508-900, São Paulo, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region><settlement type="city">São Paulo</settlement></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Toxicon</title><title level="j" type="abbrev">TOXCON</title><idno type="ISSN">0041-0101</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1994">1994</date><biblScope unit="volume">32</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1425">1425</biblScope><biblScope unit="page" to="1431">1431</biblScope></imprint><idno type="ISSN">0041-0101</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0041-0101</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Y. Cury, C. F. P. Teixeira and L. S. Sudo. Edematogenic responses induced by Bothrops jararaca venom in rats: role of lymphocytes. Toxicon32, 1425–1431, 1994.—The intraplantar injection of Bothrops jararaca venom (Bjv) caused an edematogenic response in the rat which was of rapid onset, and reached a peak in about 60 min. The response was markedly attenuated in animals rendered leucopenic by the administration of amethopterin. This inhibition was partially reverted when leucopenic rats were given i.v. suspensions of lymphocytes. Suspensions of neutrophils were ineffective. If the animals were submitted to an experimental obstruction of the thoracic duct, which leads to specific lymphocytopenia, similar inhibition of the edematogenic response was observed. These results suggest that lymphocytes can directly influence the development of the edema induced by Bothrops jararaca venom.</div></front></TEI><affiliations><list><country><li>Brésil</li></country><region><li>État de São Paulo</li></region><settlement><li>São Paulo</li></settlement><orgName><li>Université de São Paulo</li></orgName></list><tree><country name="Brésil"><region name="État de São Paulo"><name sortKey="Cury, Y" sort="Cury, Y" uniqKey="Cury Y" first="Y." last="Cury">Y. Cury</name></region><name sortKey="Sudo, L S" sort="Sudo, L S" uniqKey="Sudo L" first="L. S." last="Sudo">L. S. Sudo</name><name sortKey="Teixeira, C F P" sort="Teixeira, C F P" uniqKey="Teixeira C" first="C. F. P." last="Teixeira">C. F. P. Teixeira</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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